Decreased level of miR-1301 promotes colorectal cancer progression via activation of STAT3 pathway

Abstract The molecular pathogenesis of colorectal cancer (CRC) has been widely investigated in recent years. Accumulating evidence indicated that microRNA (miRNA) dysregulation participates the processes driving CRC initiation and progression. Aberrant expression miR-1301 found various tumor types. However, its role remains to be elucidated. In present study, we identified was enriched normal tissues significantly down-regulated CRC. Decreased level strongly correlated with aggressive pathological characteristics, including advanced stage metastasis. Bioinformatics dual luciferase assay demonstrated STAT3 is a direct target miR-1301. Gain loss-of-function assays showed had no effect on cell proliferation. Overexpression suppressed migration invasion capacity pSTAT3-positive LoVo cells, but not pSTAT3-negative SW480 while inhibition consistently promoted both lines. Additionally, restored STAT3-knockdown cells. MiR-1301 functioned as suppressor modulate IL6/STAT3 signaling pathway. summary, this study highlights significant miR-1301/STAT3 axis